IB Lab PANDA™

Pediatric Bone Age and Developmental Assessment

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Problems

Radiographic skeletal age (or bone age) assessment is widely used by pediatricians and endocrinologists as part of the clinical assessment of skeletal maturity to diagnose growth disorders. However, radiologists assessing bone age using the Greulich & Pyle method must do a manual comparison of digital radiographs from patients with reference images in an atlas, a time-consuming task with a high level of inter-rater variability.

Labor intensive

Time intensive

Subjective

Solutions

A quick and automated method to estimate bone age according to Greulich & Pyle in a standardized format enables radiologists and physicians to supply quick and accurate assessments of child growth and development. IB Lab PANDA™ is here to help

Precise

Excellent Agreement with expert readers, mean difference only 0.77 months 7

Quick results

Based on internal testing, IB Lab PANDA™ takes on average 8.4 seconds for fully automated analysis

Reliable

Using IB Lab PANDA reduced measurement differences by 5.8 months

<5

sec

Calculation time, compared to several minutes of manual lookup of the Greulich and Pyle (G&P) atlas [1]

±2.5

cm

PANDA’s automated adult height estimation is precise to ±2.5 cm [4]

60

%

of radiologists are likely to ask for PANDA to be installed in their practice

Product description

IB Lab’s diagnostic support tool IB Lab PANDA™ uses deep learning technology to report bone age based on the Greulich & Pyle scale and saves time by calculating the results within five seconds. IB Lab PANDA™’s automated bone age measurement according to Greulich & Pyle is precise to 5.3 months mean absolute deviation. IB Lab PANDA™ provides accurate data for decision making. Standardized measurements and reporting schemes facilitate monitoring of treatment progress.

IB Lab PANDA™ presents relevant clinical findings by applying international medical standards to enable timely and accurate decision making. The findings are summarized in a visual output report, attached to the original radiograph and saved automatically in the PACS system. The AI-results are fed as text into your pre-defined RIS-template for accelerated reporting. The standardized reporting enables monitoring of disease progression by facilitating comparison of radiographic disease parameters over time.

Findings

  • Pediatric bone age according to Greulich & Pyle
  • Chronological age
  • Difference in bone age to chronological age
  • Natural standard deviation (Brush tables), standard deviation score

Intended use

IB Lab PANDA uses deep learning technology to report bone age based on the Greulich & Pyle scale and saves time by presenting the results within 5 seconds. The system is to be used by trained medical professionals including, but not limited to, orthopedists and radiologists. It should not be used in-lieu of full patient evaluation or solely relied upon to make or confirm a diagnosis.

References
  1. D. G. King, D. M. Steventon, M. P. O’Sullivan, A. M. Cook, V. P. L. Hornsby, I. G. Jefferson, and P. R. King: Reproducibility of bone ages when performed by radiology registrars: an audit of Tanner and Whitehouse II versus Greulich and Pyle methods, The British Institute of Radiology, 2014.
  2. S.Serinellia, V.Panettab, P. Pasqualettib, D. Marchetti: Accuracy of three age determination X-ray methods on the left hand-wrist: A systematic review and meta-analysis, Legal Medicine, 2011.
  3. Halabi, S. S., Prevedello, L. M., Kalpathy-Cramer, J., Mamonov, A. B., Bilbily, A., Cicero, M., … Flanders, A. E.: The RSNA Pediatric Bone Age Machine Learning Challenge, Radiology, 290(2), 2018. 498–503.
  4. IB Lab Clinical Evaluation Study
  5. Simmons K, Greulich WW. 1944. The Brush Foundation Study of Child Growth and Development: II. Physical Growth and Development. Monogr. Soc. Res. Child Dev. 9(1):i–87.
  6. Greulich, W. W., Pyle, S. I.: Radiographic atlas of skeletal development of the hand and wrist (2nd edition), Stanford Univ. Press, 1959.

What our customers say:

Jack Farr - Orthopedist

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Jack Farr, MD
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The integration of the AI ​​solutions by ImageBiopsy Lab into our RIS and PACS is easy and well done. It is fun to work with and the clarity of the visualized report is an ideal support for our patient consultation.

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AI-based solutions reduce the amount of work and the findings become more accurate. An objective value is given which can be used both for monitoring and forecasting the progress. We offer something that others don’t have.

Michael Gruber, MD
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Exact diagnosis and reproducible follow-up exams are indispensable for a successful osteoarthritis therapy. Software-based methods can assist the physician in the therapy management and adjustment process.

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